The range of chromatography applications to which Dynamic Extractions High Performance Counter Current Chromatography - (HPCCC) instruments are suited includes those of chemists and chromatographers working in drug discovery; drug development; active material purification; active material isolation and trace amount isolation.
Although this liquid-liquid partition chromatography technique may be successfully applied to the separation of compounds right across the range from small synthetic to naturally occurring macromolecular species, it is particularly attractive in the following circumstances:
- Where the solubility of a sample is poor to the point of limiting throughput in existing Reverse Phase liquid chromatography purifications
- Where you want to quickly purify target compounds from crude samples, which are at an embryonic stage in their chemistry development
- Any application where target compounds are present at a low concentration in crude samples
- Where you do not want to re-develop your purification: as production scale-up proceeds it is often necessary to redevelop solid-liquid chromatographic separations.
By means of enhanced throughput, performance and selectivity, the technique provides additional chromatographic options and opportunities. Contact us to discuss how Dynamic Extractions technology can improve performance and benefit your own particular chromatographic applications.
Medicinal Chemistry
By changing and increasing the available selectivity options you can improve your liquid chromatography capability by the addition of this new chromatography toolNatural Product Isolation
Greatly increasing the speed and throughput and recovery of your purifications, while maintaining a gentle process compatible with your target compoundsPurification and Isolation
Over the last 20 years Reverse Phase (RP) solid media based preparative hplc has been increasingly used to provide high purity material. Find out how the process works in our purification and isolation guide.Large molecules
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